The important nature of those structural components of chromosomes and their role in making certain genome integrity is illustrated by a variety of scientific situations that end result from defects in elements of the telomere or kinetochore or cell cycle equipment or from inaccurate replication of even small portions of the genome (see Box). The map order of 28 microsatellite markers spanning the deletion region was obtained by a mixture of genotypic evaluation and physical mapping. They are all the time positioned to at least one side of the midline and infrequently exceed 1015 mm in diameter how hiv infection spread quality medex 1 mg.